Target Concentration Intervention (TCI) is a patient focused modification of the concept of Therapeutic Drug Monitoring (TDM). TCI differs from TDM in that the response of the patient to the drug is considered when optimising dosing regimens.
Previously in the TDM framework the patient was treated as an unidentified member of a population of patients and therapy was individualised to the level of their drug concentration. TCI, which uses much of the same basic components, individualises treatment to the individual patients’ response. The advantage principally being that pharmacists and clinical pharmacologists can now target the individual patient rather than the expected population response.